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scd1 inhibitor a939572  (ApexBio)

 
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    Structured Review

    ApexBio scd1 inhibitor a939572
    Scd1 Inhibitor A939572, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/scd1+inhibitor+a939572/scd1+inhibitors+a939572/pm39832629-100-44-47
    Average 90 stars, based on 1 article reviews
    scd1 inhibitor a939572 - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    WST-1 Assay:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Cell Culture:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Quantitative RT-PCR:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Gas Chromatography-Mass Spectrometry:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Inhibition:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    RNA Sequencing:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Comparison:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Expressing:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Knockdown:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Transfection:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Small Interfering RNA:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Control:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.

    Western Blot:

    Article Title: Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling.
    Article Snippet: Ethnopharmacological relevance: The Huangqi-Danshen decoction (HDD) is composed of Huangqi (Astragali Radix) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) and has been shown to alleviate renal fibrosis.. However, the potential therapeutic mechanisms and effective components of HDD remain unclear.. Aim of the study: Both lipid metabolism and cGAS/STING signaling play vital roles in the development and progression of renal fibrosis.



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    Image Search Results


    Membrane lipid saturation-induced UPR was suppressed in UGT8 KO HeLa cells. (A) Immunofluorescence of HeLa cells transiently expressing C-terminal FLAG-tagged mUgt8. Cells were immunostained with indicated antibodies. Scale bar, 10 μm. (B, C) The mRNA level of CHOP in WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (B) or tunicamycin (2.5 μg/ml) for 6 h (C) was quantified using qRT-PCR ( n = 3). (D–G) PERK phosphorylation of WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (D, E) or tunicamycin (2.5 μg/ml) for 6 h (F, G) were evaluated using immunoblotting (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (E, G) ( n = 3). (H–J) WT, UGT8 KO (#1) and UGT8 KO (#1) stably expressing mUgt8(WT)-FLAG or mUgt8(H358A)-FLAG HeLa cells were treated with SCD1 inhibitor (100 nM) for 24 h. PERK phosphorylation was evaluated using immunoblotting (F) (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (I) ( n = 3). The mRNA level of CHOP was quantified using qRT-PCR (J) ( n = 3). Mean ± SD. * P < 0.05, *** P < 0.001, **** P < 0.0001, ns; not significant, two-tailed unpaired t -test (B, C, E, G), one-way ANOVA with Dunnett’s multiple comparisons test (I, J).

    Journal: Journal of Biochemistry

    Article Title: Characterization of UGT8 as a monogalactosyl diacylglycerol synthase in mammals

    doi: 10.1093/jb/mvae084

    Figure Lengend Snippet: Membrane lipid saturation-induced UPR was suppressed in UGT8 KO HeLa cells. (A) Immunofluorescence of HeLa cells transiently expressing C-terminal FLAG-tagged mUgt8. Cells were immunostained with indicated antibodies. Scale bar, 10 μm. (B, C) The mRNA level of CHOP in WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (B) or tunicamycin (2.5 μg/ml) for 6 h (C) was quantified using qRT-PCR ( n = 3). (D–G) PERK phosphorylation of WT or UGT8 KO (#1) HeLa cells treated with SCD1 inhibitor (100 nM) for 24 h (D, E) or tunicamycin (2.5 μg/ml) for 6 h (F, G) were evaluated using immunoblotting (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (E, G) ( n = 3). (H–J) WT, UGT8 KO (#1) and UGT8 KO (#1) stably expressing mUgt8(WT)-FLAG or mUgt8(H358A)-FLAG HeLa cells were treated with SCD1 inhibitor (100 nM) for 24 h. PERK phosphorylation was evaluated using immunoblotting (F) (representative data of n = 2 out of n = 3 independent experiments). The ratio of phosphorylated PERK (pPERK) to total PERK was quantified (I) ( n = 3). The mRNA level of CHOP was quantified using qRT-PCR (J) ( n = 3). Mean ± SD. * P < 0.05, *** P < 0.001, **** P < 0.0001, ns; not significant, two-tailed unpaired t -test (B, C, E, G), one-way ANOVA with Dunnett’s multiple comparisons test (I, J).

    Article Snippet: The UGT8 inhibitor (compound 19) and SCD1 inhibitor (A939572) were purchased from Cayman Chemicals.

    Techniques: Membrane, Immunofluorescence, Expressing, Quantitative RT-PCR, Phospho-proteomics, Western Blot, Stable Transfection, Two Tailed Test